If you want a Hartsfiled I would build a clone, you can find the plans on the net. The original gold folded plate 537 horn lens are worth their weight in gold among hi fi collectors and will sell for it. The pro black version 2390 horn lens still sells for decent money. If you want to use authentic JBL 375 drivers those are serious money for a pair of clean working drivers with the original diaphragm, the 2440 pro version are not cheap either for clean drivers with original diaphragms. Your 2450 drivers would work though.
Back to your question, the 18 inch woofer idea would not be a good idea for a Hartsfield type of speaker project.
If you want to build a classic JBL speaker using 18 inch speakers look at a 4345 studio monitor or maybe
super size a 4350 design using 18's.
I hope your uncle got some good money when he sold his Hartsfileds, a pair of them in good condition with original drivers could easily sell for $15,000 or more on a good day.