Not sure exactly which model amp you are using, as 2406 isn't a QSC model that I'm aware of.
First guess though, if you had a gain drop and nothing else changed, is that you lost a pin on the input. Losing pin 2 or pin 3 on the XLR (or the tip or the ring on the 1/4" jack) will result in a loss of signal level.
If all of the cables test out, then check the dip switches on the amp. (if it is a model with dip switches.) Pay attention to the parallel and bridge mono input switches. Notice that there are 2 switches that need to me moved together to change between each of those functions. Move only one and it only changes one of the 2 pins. You'll get some strange results if they are not moved in pairs.