Guitar Amp to DI cable question?

Re: Guitar Amp to DI cable question?

Bennett Prescott said:
Exactly for the reasons others have stated. I don't want the DI messing up the signal going to the speaker either because of internal wire or 1/4" jacks being a miserable connector.
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My question should have been stated: Are there any sonic differences between hooking up in line vs on separate lines (other than the obvious reliability issues that 1/4" jacks have)
 
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