In a word, no... not at the same time.
The default XLR patching has buses 13 & 14 on XLR outputs 13 & 14, with XLR outputs 15 & 16 patched to main L & R. While EFX 1 is patched to BUS 13, you don't have to use it. You can unpatch it in the EFFECTS EDIT, or dedicate that effects slot to a...